CCT241533 Hydrochloride


Catalog No. Size PriceQuantity
M9973-2 Solid 2 mg $270
M9973-10 Solid 10 mg $1,050

Description

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). It shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 dihydrochloride inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells and blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Product information

CAS Number: 1431697-96-9

Molecular Weight: 478.94

Formula: C23H28ClFN4O4

Chemical Name: 4-fluoro-2-(4-{[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino}-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride

Smiles: Cl.CC(C)(O)[C@@H]1CNC[C@H]1NC1=NC(=NC2=CC(OC)=C(C=C21)OC)C1=CC(F)=CC=C1O

InChiKey: LAKJUTZIXHTMPC-SSPJITILSA-N

InChi: InChI=1S/C23H27FN4O4.ClH/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29;/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28);1H/t15-,17-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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