Description
IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.
Product information
CAS Number: 1850276-58-2
Molecular Weight: 340.37
Formula: C22H16N2O2
Chemical Name: 1-{7-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl}-2-phenylethane-1,2-dione
Smiles: CC1=CC2=NC(=C(C(=O)C(=O)C3C=CC=CC=3)N2C=C1)C1C=CC=CC=1
InChiKey: AHNNWZOVCRQAAH-UHFFFAOYSA-N
InChi: InChI=1S/C22H16N2O2/c1-15-12-13-24-18(14-15)23-19(16-8-4-2-5-9-16)20(24)22(26)21(25)17-10-6-3-7-11-17/h2-14H,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (73.45 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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