Glucose-conjugated MGMT inhibitor


Catalog No. Size PriceQuantity
M10751-2 Solid 2 mg $155
M10751-10 Solid 10 mg $480

Description

O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.

Product information

CAS Number: 382607-78-5

Molecular Weight: 616.53

Formula: C24H34BrN5O7S

Chemical Name: (2R,3R,4S,5S,6R)-2-[(8-{2-amino-6-[(4-bromothiophen-2-yl)methoxy]-9H-purin-9-yl}octyl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Smiles: NC1=NC2=C(N=CN2CCCCCCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(=N1)OCC1=CC(Br)=CS1

InChiKey: WAAZBVOGWRQLMB-PUIBNRJISA-N

InChi: InChI=1S/C24H34BrN5O7S/c25-14-9-15(38-12-14)11-36-22-17-21(28-24(26)29-22)30(13-27-17)7-5-3-1-2-4-6-8-35-23-20(34)19(33)18(32)16(10-31)37-23/h9,12-13,16,18-20,23,31-34H,1-8,10-11H2,(H2,26,28,29)/t16-,18-,19+,20-,23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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