Description
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).
Product information
CAS Number: 345651-04-9
Molecular Weight: 334.41
Formula: C20H22N4O
Chemical Name: 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethan-1-ol
Smiles: OCCN1CCN(CC1)C1=NC(=NC2=CC=CC=C21)C1C=CC=CC=1
InChiKey: DPFKMYSBAMEGQK-UHFFFAOYSA-N
InChi: InChI=1S/C20H22N4O/c25-15-14-23-10-12-24(13-11-23)20-17-8-4-5-9-18(17)21-19(22-20)16-6-2-1-3-7-16/h1-9,25H,10-15H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (747.59 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp). BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro.
Products are for research use only. Not for human use.
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