Mestranol

Mestranol is an Estrogen. The mechanism of action of mestranol is as an Estrogen Receptor Agonist. It is used as the estrogen component of many combination oral contraceptives.

Product information

CAS Number: 72-33-3

Molecular Weight: 310.43

Formula: C21H26O2

Synonym:

Devocin

Norquen

Ovastol

Ethynylestradiol 3-methyl ether

Ethinyl Estradiol 3 Methyl Ether

Ethinyl Estradiol 3-Methyl Ether

Chemical Name: 17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Smiles: CC12CCC3C(CCC4=CC(=CC=C43)OC)C1CCC2(O)C#C

InChiKey: IMSSROKUHAOUJS-UHFFFAOYSA-N

InChi: InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 15 mg/mL(48.32 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized.

In Vivo:

Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus.

References:

1. Shackelford DP Jr, et al. Brain Res Bull, 1988, 21(2), 329-333.
2. Dragan YP, et al. Carcinogenesis, 1996, 17(9), 2043-2052.

Products are for research use only. Not for human use.