Description
ZMF-24 is an anti-triple-negative breast cancer (TNBC) agent with IC50 values of 0.22 μM and 0.44 μM against TNBC proliferation in BT-549 cells and MDA-MB-231 cells, respectively. ZMF-24 inhibits Eukaryotic translation initiation factor 3 subunit D (EIF3D) that disrupts the energy supply of TNBC by inhibiting glycolysis and further induces profound TNBC apoptosis by stimulating persistent ER stress.
Product information
Molecular Weight: 567.67
Formula: C35H37NO6
Smiles: CC(C)=CCC/C(/C)=C/[C@H]1OC(=O)CC21C[C@@H](C=CC2=O)OC(=O)CC1C=CC(=CC=1)NC(=O)/C=C/C1C=CC=CC=1
InChiKey: VSFAQPHTQLVNFK-UXBSGQLDSA-N
InChi: InChI=1S/C35H37NO6/c1-24(2)8-7-9-25(3)20-31-35(23-34(40)42-31)22-29(17-18-30(35)37)41-33(39)21-27-12-15-28(16-13-27)36-32(38)19-14-26-10-5-4-6-11-26/h4-6,8,10-20,29,31H,7,9,21-23H2,1-3H3,(H,36,38)/b19-14+,25-20+/t29-,31-,35?/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.