SRS16-86 - CAS# 1793052-96-6


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M16364-C Contact sales@xcessbio.com for quotation $100

Description

SRS16-86, a novel third-generation ferrostatin, is an inhibitor of ferroptosis.

Product information

CAS Number: 1793052-96-6

Molecular Weight: 432.56

Formula: C26H32N4O2

Chemical Name: tert-butyl 4-[(adamantan-1-yl)amino]-3-{[(pyrimidin-5-yl)methylidene]amino}benzoate

Smiles: CC(C)(C)OC(=O)C1=CC(N=CC2C=NC=NC=2)=C(C=C1)NC12CC3CC(C1)CC(C2)C3

InChiKey: DFENTOUMMDWZAF-FDVSRXAVSA-N

InChi: InChI=1S/C26H32N4O2/c1-25(2,3)32-24(31)21-4-5-22(23(9-21)29-15-20-13-27-16-28-14-20)30-26-10-17-6-18(11-26)8-19(7-17)12-26/h4-5,9,13-19,30H,6-8,10-12H2,1-3H3/b29-15-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C). DMSO: 5 mg/mL(11.55 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SRS16-86 exhibits ferroptosis-inhibiting ability in vitro by FACS analysis of erastin-treated HT-1080 cells and in NIH 3T3 cells.

In Vivo:

SRS16-86 (a novel third-generation ferrostatin) is more stable, to metabolism and plasma, and more potent, compared with the first-in-class compound ferrostatin-1 (Fer-1) to suppress ferroptosis in vivo. Even in conditions with extraordinarily severe IRI, SRS16-86 exerts strong protection to an extent which has not previously allowed survival in any murine setting.

Products are for research use only. Not for human use.

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