FGFR1 inhibitor-2 - CAS# 2410612-08-5


Catalog No. Size PriceQuantity
M17769-C Contact sales@xcessbio.com for quotation $100

Description

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer.

Product information

CAS Number: 2410612-08-5

Molecular Weight: 507.45

Formula: C25H22F5N3O3

Chemical Name: 1-(5, 5-bis(4-fluorophenyl)pentyl)-3-(4-nitro-3-(trifluoromethyl)phenyl)urea

Smiles: [O-][N+](=O)C1=CC=C(C=C1C(F)(F)F)NC(=O)NCCCCC(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1

InChiKey: PYHZCSUPIZNJGX-UHFFFAOYSA-N

InChi: InChI=1S/C25H22F5N3O3/c26-18-8-4-16(5-9-18)21(17-6-10-19(27)11-7-17)3-1-2-14-31-24(34)32-20-12-13-23(33(35)36)22(15-20)25(28,29)30/h4-13,15,21H,1-3,14H2,(H2,31,32,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1. FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM.

Products are for research use only. Not for human use.

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