BSc5371 - CAS# 2286419-03-0


Catalog No. Size PriceQuantity
M17393-C Contact sales@xcessbio.com for quotation $100

Description

BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines.

Product information

CAS Number: 2286419-03-0

Molecular Weight: 485.60

Formula: C24H31N5O4S

Chemical Name: N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-ethenesulfonamido-2-oxo-2, 3-dihydro-1H-indol-3-ylidene]methyl}-2, 4-dimethyl-1H-pyrrole-3-carboxamide

Smiles: CC1NC(/C=C2/C3=CC(=CC=C3NC/2=O)NS(=O)(=O)C=C)=C(C)C=1C(=O)NCCN(CC)CC

InChiKey: OXJJSKDUGJXXAV-RGEXLXHISA-N

InChi: InChI=1S/C24H31N5O4S/c1-6-29(7-2)12-11-25-24(31)22-15(4)21(26-16(22)5)14-19-18-13-17(28-34(32,33)8-3)9-10-20(18)27-23(19)30/h8-10,13-14,26,28H,3,6-7,11-12H2,1-2,4-5H3,(H,25,31)(H,27,30)/b19-14-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BSc5371 (5 μM-0.5 nM, 77 hours) exhibits inhibitory activity against FLT3-mutated (MV4-11) cells, with an IC50 of 6 nM.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed