Description
BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines.
Product information
CAS Number: 2286419-03-0
Molecular Weight: 485.60
Formula: C24H31N5O4S
Chemical Name: N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-ethenesulfonamido-2-oxo-2, 3-dihydro-1H-indol-3-ylidene]methyl}-2, 4-dimethyl-1H-pyrrole-3-carboxamide
Smiles: CC1NC(/C=C2/C3=CC(=CC=C3NC/2=O)NS(=O)(=O)C=C)=C(C)C=1C(=O)NCCN(CC)CC
InChiKey: OXJJSKDUGJXXAV-RGEXLXHISA-N
InChi: InChI=1S/C24H31N5O4S/c1-6-29(7-2)12-11-25-24(31)22-15(4)21(26-16(22)5)14-19-18-13-17(28-34(32,33)8-3)9-10-20(18)27-23(19)30/h8-10,13-14,26,28H,3,6-7,11-12H2,1-2,4-5H3,(H,25,31)(H,27,30)/b19-14-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BSc5371 (5 μM-0.5 nM, 77 hours) exhibits inhibitory activity against FLT3-mutated (MV4-11) cells, with an IC50 of 6 nM.
Products are for research use only. Not for human use.
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