AZD1080


Catalog No. Size PriceQuantity
M9635-2 Solid 2 mg $100
M9635-10 Solid 10 mg $300

Description

AZD-1080 is a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies. AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD1080 reverses MK-801-induced deficits, measured by long-term potentiation in hippocampal slices and in a cognitive test in mice, suggesting that reversal of synaptic plasticity deficits in dysfunctional systems requires longer term modifications of proteins downstream of GSK3β signaling.

Product information

CAS Number: 612487-72-6

Molecular Weight: 334.37

Formula: C19H18N4O2

Chemical Name: 2-hydroxy-3-{5-[(morpholin-4-yl)methyl]pyridin-2-yl}-1H-indole-5-carbonitrile

Smiles: N#CC1C=C2C(=C(O)NC2=CC=1)C1=CC=C(CN2CCOCC2)C=N1

InChiKey: BLTVBQXJFVRPFK-UHFFFAOYSA-N

InChi: InChI=1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed