Description
Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.
Product information
CAS Number: 254877-67-3
Molecular Weight: 576.49
Formula: C21H19Cl2N3O6S3
Chemical Name: 5-chloro-2-(5-chlorothiophene-2-sulfonamido)-N-[4-(morpholine-4-sulfonyl)phenyl]benzamide
Smiles: O=C(NC1C=CC(=CC=1)S(=O)(=O)N1CCOCC1)C1=CC(Cl)=CC=C1NS(=O)(=O)C1=CC=C(Cl)S1
InChiKey: PQHLRGARXNPFCF-UHFFFAOYSA-N
InChi: InChI=1S/C21H19Cl2N3O6S3/c22-14-1-6-18(25-34(28,29)20-8-7-19(23)33-20)17(13-14)21(27)24-15-2-4-16(5-3-15)35(30,31)26-9-11-32-12-10-26/h1-8,13,25H,9-12H2,(H,24,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (173.46 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings. Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells. Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol.
Products are for research use only. Not for human use.
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