Description
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 µM and a KD of 1.1 µM. Anticancer agent.
Product information
CAS Number: 313964-19-1
Molecular Weight: 335.66
Formula: C12H6ClN5O5
Chemical Name: N-(4-chloro-3-nitrophenyl)-4-nitrobenzo[c][1, 2, 5]oxadiazol-5-amine
Smiles: [O-][N+](=O)C1=CC(=CC=C1Cl)NC1C=CC2=NON=C2C=1[N+]([O-])=O
InChiKey: PQZKMXPISWCLCU-UHFFFAOYSA-N
InChi: InChI=1S/C12H6ClN5O5/c13-7-2-1-6(5-10(7)17(19)20)14-9-4-3-8-11(16-23-15-8)12(9)18(21)22/h1-5,14H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain.
Products are for research use only. Not for human use.
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