DDO-5936 - CAS# 2355377-13-6


Catalog No. Size PriceQuantity
M16600-C Contact sales@xcessbio.com for quotation $100

Description

DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer.

Product information

CAS Number: 2355377-13-6

Molecular Weight: 495.59

Formula: C25H29N5O4S

Chemical Name: 2-[N-(4-{[2-(pyrrolidin-1-yl)pyrimidin-4-yl]amino}phenyl)2,4,6-trimethylbenzenesulfonamido]acetic acid

Smiles: CC1C=C(C)C=C(C)C=1S(=O)(=O)N(CC(O)=O)C1C=CC(=CC=1)NC1=CC=NC(=N1)N1CCCC1

InChiKey: IIPYRKNROAWEPK-UHFFFAOYSA-N

InChi: InChI=1S/C25H29N5O4S/c1-17-14-18(2)24(19(3)15-17)35(33,34)30(16-23(31)32)21-8-6-20(7-9-21)27-22-10-11-26-25(28-22)29-12-4-5-13-29/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H,31,32)(H,26,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.

In Vivo:

DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency.

Products are for research use only. Not for human use.

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