Remacemide hydrochloride - CAS# 111686-79-4


Catalog No. Size PriceQuantity
M16487-C Contact sales@xcessbio.com for quotation $100

Description

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.

Product information

CAS Number: 111686-79-4

Molecular Weight: 304.81

Formula: C17H21ClN2O

Chemical Name: 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride

Smiles: Cl.CC(CC1C=CC=CC=1)(NC(=O)CN)C1C=CC=CC=1

InChiKey: HYQMIUSWZXGTCC-UHFFFAOYSA-N

InChi: InChI=1S/C17H20N2O.ClH/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14;/h2-11H,12-13,18H2,1H3,(H,19,20);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM.

In Vivo:

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.

Products are for research use only. Not for human use.

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