BMS-986242 - CAS# 1923844-48-7


Catalog No. Size PriceQuantity
M16517-C Contact sales@xcessbio.com for quotation $100

Description

BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer.

Product information

CAS Number: 1923844-48-7

Molecular Weight: 410.91

Formula: C24H24ClFN2O

Chemical Name: 4-chloro-N-((R)-1-((1s, 4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide

Smiles: C[C@@H](NC(=O)C1C=CC(Cl)=CC=1)[C@@H]1CC[C@@H](CC1)C1=CC=NC2=CC=C(F)C=C12

InChiKey: AOJCHFNHRLPISK-ZACQAIPSSA-N

InChi: InChI=1S/C24H24ClFN2O/c1-15(28-24(29)18-6-8-19(25)9-7-18)16-2-4-17(5-3-16)21-12-13-27-23-11-10-20(26)14-22(21)23/h6-17H,2-5H2,1H3,(H,28,29)/t15-,16-,17+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (608.41 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ∼20 % max inhibition).

In Vivo:

BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) exhibits dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses.

Products are for research use only. Not for human use.

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