Peramivir (trihydrate)

Peramivir, also known as BCX1812 and RWJ 270201, is an antiviral drug for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. Peramivir was approved to treat influenza infection in adults. (http://en.wikipedia.org/wiki/Peramivir).

Product information

CAS Number: 1041434-82-5

Molecular Weight: 382.45

Formula: C15H34N4O7

Synonym:

RWJ 270201 trihydrate

Rapiacta trihydrate

BCX 1812 trihydrate

Chemical Name: (1S,2S,3S,4R)-4-[(diaminomethylidene)amino]-3-[(1S)-1-acetamido-2-ethylbutyl]-2-hydroxycyclopentane-1-carboxylic acid trihydrate

Smiles: O.O.O.CC(=O)N[C@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(O)=O)N=C(N)N)C(CC)CC

InChiKey: RFUCJKFZFXNIGB-ZBBHRWOZSA-N

InChi: InChI=1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 5 mg/mL (13.07 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Babu YS, et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem. 2000 Sep 21;43(19):3482-6.
2. Young D, et al. RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13.

Products are for research use only. Not for human use.