Echistatin - CAS# 154303-05-6

Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1.

Product information

CAS Number: 154303-05-6

Molecular Weight: 5417.05

Formula: C217H341N71O74S9

Chemical Name: 5-[[15a-[2-[[1-[[4-amino-1-[2-[[1-[[6-amino-1-[[2-[2-[[1-[(1-carboxy-2-hydroxypropyl)amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1, 4-dioxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-4a, 35, 44, 62-tetrakis(4-aminobutyl)-26a, 98-bis(2-amino-2-oxoethyl)-38-benzyl-56-butan-2-yl-29a, 65, 71-tris(3-carbamimidamidopropyl)-24, 47-bis(2-carboxyethyl)-12a, 77, 80, 86, 89-pentakis(carboxymethyl)-7a, 53-bis(1-hydroxyethyl)-21-(hydroxymethyl)-92-[(4-hydroxyphenyl)methyl]-68-methyl-41-(2-methylpropyl)-83-(2-methylsulfanylethyl)-2a, 5a, 8, 8a, 10a, 11, 13a, 17, 20, 23, 25a, 26, 28a, 31a, 33, 36, 39, 42, 45, 48, 51, 54, 57, 60, 63, 66, 69, 72, 75, 78, 81, 84, 87, 90, 93, 96, 99-heptatriacontaoxo-3, 4, 17a, 18a, 21a, 22a, 29, 30-octathia-a, 3a, 6a, 7, 9a, 10, 11a, 14a, 16, 19, 22, 24a, 25, 27a, 30a, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 73, 76, 79, 82, 85, 88, 91, 94, 97-heptatriacontazapentacyclo[57.50.10.86, 32.49, 95.012, 16]hentriacontahectan-27-yl]amino]-4-amino-5-oxopentanoic acid

Smiles: CC(C)CC1NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCCCN)NC(=O)C2CSSCC(NC(=O)C(N)CCC(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CO)C(=O)NCC(=O)N3CCCC3C(=O)NC3CSSCC4NC(=O)C(CC5=CC=C(O)C=C5)NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCCN)NC(=O)C(CSSCC(NC(=O)C(CC(O)=O)NC(=O)C(CSSCC(NC3=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(N)=O)C(=O)N2)NC(=O)C(NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC4=O)C(C)O)C(=O)N2CCCC2C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(N)=O)C(=O)N2CCCC2C(=O)NC(CC2=CNC=N2)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(C)C(=O)NC(C(C)O)C(O)=O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CCCCN)NC1=O)C(C)O)C(C)CC

InChiKey: KZMZKUVIDVBQGX-UHFFFAOYSA-N

InChi: InChI=1S/C217H341N71O74S9/c1-11-102(4)166-208(356)278-143-97-370-371-99-145(212(360)288-71-32-46-148(288)206(354)260-121(43-28-67-239-217(233)234)183(331)271-136(79-152(226)296)211(359)287-70-31-47-149(287)207(355)270-128(76-110-85-235-100-245-110)190(338)251-113(35-15-20-59-218)174(322)243-89-156(300)285-68-29-44-146(285)204(352)247-104(6)171(319)284-169(107(9)292)213(361)362)280-196(344)135(84-165(316)317)269-202(350)144-98-369-366-94-140-199(347)256-120(42-27-66-238-216(231)232)182(330)265-130(78-151(225)295)191(339)275-139(198(346)255-118(39-19-24-63-222)181(329)262-126(74-108-33-13-12-14-34-108)188(336)261-125(73-101(2)3)187(335)253-116(37-17-22-61-220)180(328)257-122(53-56-159(304)305)175(323)241-88-155(299)281-167(105(7)290)210(358)282-166)93-365-364-92-138(273-172(320)112(223)52-55-158(302)303)197(345)258-123(54-57-160(306)307)184(332)272-137(91-289)177(325)244-90-157(301)286-69-30-45-147(286)205(353)277-142(203(351)276-140)96-368-367-95-141(201(349)264-129(77-150(224)294)176(324)242-86-153(297)248-115(36-16-21-60-219)186(334)283-168(106(8)291)209(357)279-144)274-189(337)127(75-109-48-50-111(293)51-49-109)263-194(342)134(83-164(314)315)268-195(343)133(82-163(312)313)266-185(333)124(58-72-363-10)259-193(341)132(81-162(310)311)267-192(340)131(80-161(308)309)249-154(298)87-240-173(321)114(40-25-64-236-214(227)228)250-170(318)103(5)246-178(326)119(41-26-65-237-215(229)230)252-179(327)117(254-200(143)348)38-18-23-62-221/h12-14,33-34,48-51,85,100-107,112-149,166-169,289-293H,11,15-32,35-47,52-84,86-99,218-223H2,1-10H3,(H2,224,294)(H2,225,295)(H2,226,296)(H,235,245)(H,240,321)(H,241,323)(H,242,324)(H,243,322)(H,244,325)(H,246,326)(H,247,352)(H,248,297)(H,249,298)(H,250,318)(H,251,338)(H,252,327)(H,253,335)(H,254,348)(H,255,346)(H,256,347)(H,257,328)(H,258,345)(H,259,341)(H,260,354)(H,261,336)(H,262,329)(H,263,342)(H,264,349)(H,265,330)(H,266,333)(H,267,340)(H,268,343)(H,269,350)(H,270,355)(H,271,331)(H,272,332)(H,273,320)(H,274,337)(H,275,339)(H,276,351)(H,277,353)(H,278,356)(H,279,357)(H,280,344)(H,281,299)(H,282,358)(H,283,334)(H,284,319)(H,302,303)(H,304,305)(H,306,307)(H,308,309)(H,310,311)(H,312,313)(H,314,315)(H,316,317)(H,361,362)(H4,227,228,236)(H4,229,230,237)(H4,231,232,238)(H4,233,234,239)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.
2. M Sato, et al. Echistatin is a potent inhibitor of bone resorption in culture. J Cell Biol. 1990 Oct;111(4):1713-23.
3. C C Kumar, et al. Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):843-53.
4. I Wierzbicka-Patynowski, et al. Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins. J Biol Chem. 1999 Dec 31;274(53):37809-14.

Products are for research use only. Not for human use.