RO0270608 - CAS# 220846-33-3


Catalog No. Size PriceQuantity
M16612-C Contact sales@xcessbio.com for quotation $100

Description

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity.

Product information

CAS Number: 220846-33-3

Molecular Weight: 505.78

Formula: C24H19Cl3N2O4

Chemical Name: (2S)-2-[(2-chloro-6-methylphenyl)formamido]-3-[4-(2,6-dichlorobenzamido)phenyl]propanoic acid

Smiles: CC1=CC=CC(Cl)=C1C(=O)N[C@@H](CC1C=CC(=CC=1)NC(=O)C1C(Cl)=CC=CC=1Cl)C(O)=O

InChiKey: JTVWJXUGGJTGDA-IBGZPJMESA-N

InChi: InChI=1S/C24H19Cl3N2O4/c1-13-4-2-5-16(25)20(13)22(30)29-19(24(32)33)12-14-8-10-15(11-9-14)28-23(31)21-17(26)6-3-7-18(21)27/h2-11,19H,12H2,1H3,(H,28,31)(H,29,30)(H,32,33)/t19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM).

In Vivo:

In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed