Description
RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity.
Product information
CAS Number: 220846-33-3
Molecular Weight: 505.78
Formula: C24H19Cl3N2O4
Chemical Name: (2S)-2-[(2-chloro-6-methylphenyl)formamido]-3-[4-(2,6-dichlorobenzamido)phenyl]propanoic acid
Smiles: CC1=CC=CC(Cl)=C1C(=O)N[C@@H](CC1C=CC(=CC=1)NC(=O)C1C(Cl)=CC=CC=1Cl)C(O)=O
InChiKey: JTVWJXUGGJTGDA-IBGZPJMESA-N
InChi: InChI=1S/C24H19Cl3N2O4/c1-13-4-2-5-16(25)20(13)22(30)29-19(24(32)33)12-14-8-10-15(11-9-14)28-23(31)21-17(26)6-3-7-18(21)27/h2-11,19H,12H2,1H3,(H,28,31)(H,29,30)(H,32,33)/t19-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC50=30 nM).
In Vivo:
In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation
Products are for research use only. Not for human use.
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