HS271 - CAS# 2410393-15-4


Catalog No. Size PriceQuantity
M17455-C Contact sales@xcessbio.com for quotation $100

Description

HS271 is a highly potent, orally active and selective IRAK4 inhibitor, with an IC50 of 7.2 μM. HS271 exhibits superior enzymatic and cellular activities, as well as excellent pharmacokinetic properties.

Product information

CAS Number: 2410393-15-4

Molecular Weight: 435.44

Formula: C21H24F3N5O2

Chemical Name: N-{2-[2-(dimethylamino)ethyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide

Smiles: CC(C)(O)C1=CC2=NN(CCN(C)C)C=C2C=C1NC(=O)C1C=CC=C(N=1)C(F)(F)F

InChiKey: QAOWCAZEVIIQTF-UHFFFAOYSA-N

InChi: InChI=1S/C21H24F3N5O2/c1-20(2,31)14-11-16-13(12-29(27-16)9-8-28(3)4)10-17(14)26-19(30)15-6-5-7-18(25-15)21(22,23)24/h5-7,10-12,31H,8-9H2,1-4H3,(H,26,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (229.65 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

HS271 (15-150 mg/kg) displays robust in vivo antiinflammatory efficacy as evaluated in rat models of LPS induced TNFα production collageninduced arthritis. HS271 exhibits a t1/2 of 3.3 h and Cmax of 2107 ng/mL. HS271 is stable in liver microsome assays across other species, including rat, mouse, monkey, and human. HS271 exhibits oral bioavailability of 67.3%, 58.2%, 14.4&% and 49% in mouse, rat, dog and monkey, respectively.

Products are for research use only. Not for human use.

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