Description
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer.
Product information
CAS Number: 227010-33-5
Molecular Weight: 301.17
Formula: C13H9F3Se
Chemical Name: phenyl(4-(trifluoromethyl)phenyl)selane
Smiles: FC(F)(F)C1C=CC(=CC=1)[Se]C1C=CC=CC=1
InChiKey: WJNWVLLRQJFFTC-UHFFFAOYSA-N
InChi: InChI=1S/C13H9F3Se/c14-13(15,16)10-6-8-12(9-7-10)17-11-4-2-1-3-5-11/h1-9H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS.
Products are for research use only. Not for human use.
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