Description
4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.
Product information
CAS Number: 928853-86-5
Molecular Weight: 313.42
Formula: C16H19N5S
Chemical Name: 7-methyl-5-(4-methylpiperazin-1-yl)-2-thia-4, 6, 9-triazatricyclo[8.4.0.0, ]tetradeca-1(10), 3, 5, 7, 11, 13-hexaene
Smiles: CN1CCN(CC1)C1N=C2SC3=CC=CC=C3NC2=C(C)N=1
InChiKey: HYPHGMNLWIKEMB-UHFFFAOYSA-N
InChi: InChI=1S/C16H19N5S/c1-11-14-15(22-13-6-4-3-5-12(13)18-14)19-16(17-11)21-9-7-20(2)8-10-21/h3-6,18H,7-10H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 7.69 mg/mL (24.54 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
4-MMPB has an IC50 of 69.6 μM for DPPH bleaching. 4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines. 4-MMPB (41.48 µM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
References:
- M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6.
- Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.
- Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132.
Products are for research use only. Not for human use.
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