Description
Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder
Product information
CAS Number: 14611-51-9
Molecular Weight: 187.28
Formula: C13H17N
Chemical Name: methyl[(2R)-1-phenylpropan-2-yl](prop-2-yn-1-yl)amine
Smiles: C[C@H](CC1C=CC=CC=1)N(C)CC#C
InChiKey: MEZLKOACVSPNER-GFCCVEGCSA-N
InChi: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Selegiline (1 nM-1 μM) inhibits recombinant human MAO-B in a concentration-dependent manner. Selegiline (10 mM) increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner.
In Vivo:
Selegiline (1 mg/kg; i.p. daily for 24 days) reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline reduces 3, 4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex. Animal Model: Male C57BL/6J mice (20-22 g) Dosage: 1 mg/kg Administration: I.p. daily for 24 days Result: Single injection did not acutely affect mouse locomotor activity. 14 consecutive days administration did not affect food reward. Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.
Products are for research use only. Not for human use.
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