Description
ST-2825 is MyD88 inhibitor. ST2825 provides neuroprotection after experimental traumatic brain injury in mice. ST2825 significantly inhibited the proliferation of and promoted the apoptosis of HCC cells. Moreover, ST2825 significantly decreased bcl-2 expression, increased cleaved caspase-3 expression (P < 0.05), and reduced p65 nuclear expression (P < 0.05) in a dose-dependent manner. ST2825 inhibits the proliferation of and promotes the apoptosis of HCC cells, thereby suggesting that ST2825 may be a new drug for HCC treatment.
Product information
CAS Number: 894787-30-5
Molecular Weight: 591.51
Formula: C27H28Cl2N4O5S
Chemical Name: (2R,4'R,8'aR)-1-(2-{4-[2-(2,4-dichlorophenoxy)acetamido]phenyl}acetyl)-6'-oxo-hexahydrospiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide
Smiles: NC(=O)[C@H]1CCS[C@@H]2C[C@]3(CCCN3C(=O)CC3C=CC(=CC=3)NC(=O)COC3=CC=C(Cl)C=C3Cl)C(=O)N21
InChiKey: HBLHLJXFIPCEMW-ZJSFPPFMSA-N
InChi: InChI=1S/C27H28Cl2N4O5S/c28-17-4-7-21(19(29)13-17)38-15-22(34)31-18-5-2-16(3-6-18)12-23(35)32-10-1-9-27(32)14-24-33(26(27)37)20(25(30)36)8-11-39-24/h2-7,13,20,24H,1,8-12,14-15H2,(H2,30,36)(H,31,34)/t20-,24-,27-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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