Description
GR-103545 is a reference and non-radio labeled agent. The radio-labeled 11C-GR103545 is a promising PET radiotracer for imaging the κ-OR.
Product information
CAS Number: 126766-43-6
Molecular Weight: 530.40
Formula: C23H29Cl2N3O7
Chemical Name: (2E)-but-2-enedioic acid; methyl (3R)-4-[2-(3, 4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate
Smiles: COC(=O)N1C[C@@H](CN2CCCC2)N(CC1)C(=O)CC1=CC(Cl)=C(Cl)C=C1.OC(=O)/C=C/C(O)=O
InChiKey: ABTNETSDXZBJTE-WMQZXYHMSA-N
InChi: InChI=1S/C19H25Cl2N3O3.C4H4O4/c1-27-19(26)23-8-9-24(15(13-23)12-22-6-2-3-7-22)18(25)11-14-4-5-16(20)17(21)10-14;5-3(6)1-2-4(7)8/h4-5,10,15H,2-3,6-9,11-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t15-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Vanz F, Bicca MA, Linartevichi VF, Giachero M, Bertoglio LJ, Monteiro de Lima TC. Role of dorsal hippocampus κ opioid receptors in contextual aversive memory consolidation in rats. Neuropharmacology. 2018 Jun;135:253-267. doi: 10.1016/j.neuropharm.2018.02.029. Epub 2018 Feb 27. PMID: 29499274.
- Miller JM, Zanderigo F, Purushothaman PD, DeLorenzo C, Rubin-Falcone H, Ogden RT, Keilp J, Oquendo MA, Nabulsi N, Huang YH, Parsey RV, Carson RE, Mann JJ. Kappa opioid receptor binding in major depression: A pilot study. Synapse. 2018 Sep;72(9):e22042. doi: 10.1002/syn.22042. Epub 2018 Jul 17. PMID: 29935119; PMCID: PMC7599086.
Products are for research use only. Not for human use.
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