Description
NHS-Modified MMAF (WO2012143499A2, intermediat 210) is an intermediate which can be used for producing the anti-mesothelin binder-drug conjugates (ADCs).
Product information
CAS Number: 1404073-10-4
Molecular Weight: 1051.32
Formula: C55H86N8O12
Chemical Name: 2, 5-dioxopyrrolidin-1-yl (3R, 4S, 7S, 10S)-3-(2-((S)-2-((1R, 2R)-3-(((S)-3-(1H-indol-3-yl)-1-(1, 2-oxazinan-2-yl)-1-oxopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-oxoethyl)-4-((S)-sec-butyl)-7, 10-diisopropyl-5, 11-dimethyl-6, 9-dioxo-2-oxa-5, 8, 11-triazaheptadecan-17-oate
Smiles: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(=O)N1CCCCO1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCC(=O)ON1C(=O)CCC1=O)C(C)C
InChiKey: UTWYTYXLUHOUMT-AHDRROQBSA-N
InChi: InChI=1S/C55H86N8O12/c1-12-36(6)50(60(9)55(71)48(34(2)3)58-53(69)49(35(4)5)59(8)27-17-13-14-24-47(67)75-63-44(64)25-26-45(63)65)43(72-10)32-46(66)61-28-20-23-42(61)51(73-11)37(7)52(68)57-41(54(70)62-29-18-19-30-74-62)31-38-33-56-40-22-16-15-21-39(38)40/h15-16,21-22,33-37,41-43,48-51,56H,12-14,17-20,23-32H2,1-11H3,(H,57,68)(H,58,69)/t36-,37+,41-,42-,43+,48-,49-,50-,51+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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