Description
SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation.
Product information
CAS Number: 1221418-42-3
Molecular Weight: 383.39
Formula: C20H19F2N5O
Chemical Name: 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazole-1-carbonyl)piperazine
Smiles: O=C(N1C=NC=N1)N1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
InChiKey: UIOVHJYJUUSVIG-UHFFFAOYSA-N
InChi: InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SAR629 is a potent dual inhibitory action on MAGL and fatty acid amide hydrolase (FAAH). SAR629 inhibits rodent monoglyceride lipase (MGL) activity at subnanomolar potencies (IC50 values of 1.1 nM and 219 pM in rat and mouse brain membranes, respectively).
Products are for research use only. Not for human use.
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