Description
Ribocil-C Racemate is the racemate of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.
Product information
CAS Number: 2309762-18-1
Molecular Weight: 419.50
Formula: C21H21N7OS
Chemical Name: 2-(1-{[1-(pyrimidin-2-yl)-1H-imidazol-4-yl]methyl}piperidin-3-yl)-6-(thiophen-2-yl)-1,4-dihydropyrimidin-4-one
Smiles: O=C1C=C(NC(=N1)C1CN(CC2=CN(C=N2)C2N=CC=CN=2)CCC1)C1=CC=CS1
InChiKey: UVDVCDUBJWYRJW-UHFFFAOYSA-N
InChi: InChI=1S/C21H21N7OS/c29-19-10-17(18-5-2-9-30-18)25-20(26-19)15-4-1-8-27(11-15)12-16-13-28(14-24-16)21-22-6-3-7-23-21/h2-3,5-7,9-10,13-15H,1,4,8,11-12H2,(H,25,26,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 30 mg/mL (71.51 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth.
In Vivo:
Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.
Products are for research use only. Not for human use.
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