Description
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
Product information
CAS Number: 2210228-45-6
Molecular Weight: 475.56
Formula: C26H25N3O4S
Chemical Name: 4'-[(1-cyclopropanecarbonyl-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl]-[1,1'-biphenyl]-3-carboxamide
Smiles: NC(=O)C1=CC(=CC=C1)C1C=CC(=CC=1)S(=O)(=O)NC1=CC=C2CCCN(C2=C1)C(=O)C1CC1
InChiKey: XGGNCZLDTJOSFV-UHFFFAOYSA-N
InChi: InChI=1S/C26H25N3O4S/c27-25(30)21-4-1-3-20(15-21)17-9-12-23(13-10-17)34(32,33)28-22-11-8-18-5-2-14-29(24(18)16-22)26(31)19-6-7-19/h1,3-4,8-13,15-16,19,28H,2,5-7,14H2,(H2,27,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (210.28 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), than their control shGFP counterparts. SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression.
In Vivo:
SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice.
Products are for research use only. Not for human use.
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