SU0268 - CAS# 2210228-45-6


Catalog No. Size PriceQuantity
M16947-C Contact sales@xcessbio.com for quotation $100

Description

SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.

Product information

CAS Number: 2210228-45-6

Molecular Weight: 475.56

Formula: C26H25N3O4S

Chemical Name: 4'-[(1-cyclopropanecarbonyl-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl]-[1,1'-biphenyl]-3-carboxamide

Smiles: NC(=O)C1=CC(=CC=C1)C1C=CC(=CC=1)S(=O)(=O)NC1=CC=C2CCCN(C2=C1)C(=O)C1CC1

InChiKey: XGGNCZLDTJOSFV-UHFFFAOYSA-N

InChi: InChI=1S/C26H25N3O4S/c27-25(30)21-4-1-3-20(15-21)17-9-12-23(13-10-17)34(32,33)28-22-11-8-18-5-2-14-29(24(18)16-22)26(31)19-6-7-19/h1,3-4,8-13,15-16,19,28H,2,5-7,14H2,(H2,27,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (210.28 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MTH1-depleted cells are less sensitive to the OGG1-specific inhibitor, SU0268 (5-10 μM), than their control shGFP counterparts. SU0268/IACS-4759 (5-20 μM, 48h) co-treated cells are more viable than the correspondingly-treated IACS-4759- or SU0268-treated cells. SU0268 does not bind DNA and thus interacts with OGG1 specifically rather than its substrate. SU0268 induces the release of type I IFN by the mitochondrial DNA-cGAS-STING-IRF3-IFN-β axis, which decreases bacterial loads and halts disease progression.

In Vivo:

SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed