Description
Lifirafenib hydrochloride (BGB-283 hydrochloride) is a novel, reversible B-RAFV600E inhibitor with antitumor activity. Lifirafenib has shown potent antitumor activity against solid tumors with B-RAFV600E mutations, such as melanoma, thyroid cancer, and low-grade serous ovarian cancer. Lifirafenib exhibits selective cytotoxicity in vitro, preferentially inhibiting the proliferation of cancer cells with B-RAFV600E and EGFR mutations/amplification. Lifirafenib can achieve dose-dependent inhibition of tumor growth in animal models, accompanied by partial and complete tumor shrinkage.
Product information
CAS Number: 2025320-97-0
Molecular Weight: 514.88
Formula: C25H18ClF3N4O3
Smiles: Cl.O=C1CCC2C(N1)=NC=CC=2OC1C=C2[C@@H]3[C@H](OC2=CC=1)[C@H]3C1NC2=CC(=CC=C2N=1)C(F)(F)F
InChiKey: QJAXJBSVURJFCX-SGIIKHNDSA-N
InChi: InChI=1S/C25H17F3N4O3.ClH/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23;/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33);1H/t20-,21-,22-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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