Description
TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.****Please also see similar products: TPT-197; TPT-260; TPT-172.
Product information
CAS Number: 2076-91-7
Molecular Weight: 333.32
Formula: C8H14Cl2N4S3
Synonym:
NSC55712
TPT260 Dihydrochloride
TPT 260 Dihydrochloride
TPU-260 Dihydrochloride
Chemical Name: [({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
Smiles: Cl.Cl.NC(=N)SCC1=CC=C(CSC(N)=N)S1
InChiKey: DSODRWWHAUGSGD-UHFFFAOYSA-N
InChi: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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