PHPS1 - CAS# 314291-83-3


Catalog No. Size PriceQuantity
M16902-C Contact sales@xcessbio.com for quotation $100

Description

PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

Product information

CAS Number: 314291-83-3

Molecular Weight: 465.44

Formula: C21H15N5O6S

Chemical Name: 4-{2-[5-(4-nitrophenyl)-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl]diazen-1-yl}benzene-1-sulfonic acid

Smiles: [O-][N+](=O)C1C=CC(=CC=1)C1NN(C2C=CC=CC=2)C(=O)C=1N=NC1C=CC(=CC=1)S(O)(=O)=O

InChiKey: IYPHPQODKSHEHV-GHVJWSGMSA-N

InChi: InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,24H,(H,30,31,32)/b23-22+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells. PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.

In Vivo:

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr-/- mice less susceptible to atherosclerosis development.

Products are for research use only. Not for human use.

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