Description
GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki = 21 nM).
Product information
CAS Number: 1032754-81-6
Molecular Weight: 504.63
Formula: C21H28N8O3S2
Chemical Name: 5-{6-[(4-methanesulfonylpiperazin-1-yl)methyl]-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-2-yl}pyrimidin-2-amine
Smiles: CC1C2=NC(=NC(=C2SC=1CN1CCN(CC1)S(C)(=O)=O)N1CCOCC1)C1=CN=C(N)N=C1
InChiKey: AKKCGLXULFRAET-UHFFFAOYSA-N
InChi: InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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