GDC-0077 - CAS# 2060571-02-8


Catalog No. Size PriceQuantity
M17007-C Contact sales@xcessbio.com for quotation $100

Description

GDC-0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.

Product information

CAS Number: 2060571-02-8

Molecular Weight: 407.37

Formula: C18H19F2N5O4

Chemical Name: 2-({4-[4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-9-oxa-3,6-diazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),2,4,11,13-pentaen-12-yl}amino)propanamide

Smiles: CC(NC1=CC2OCCN3C=C(N=C3C=2C=C1)N1C(COC1=O)C(F)F)C(N)=O

InChiKey: SGEUNORSOZVTOL-UHFFFAOYSA-N

InChi: InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C). DMSO: 81 mg/mL(198.83 mM). Water: Insoluble.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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