Description
Daphnetin is a coumarin derivative that has been isolated from plants of the genus Daphne and has diverse biological activities, including kinase inhibitory, anti-proliferative, and antioxidative properties.
Product information
CAS Number: 486-35-1
Molecular Weight: 178.14
Formula: C9H6O4
Synonym:
NSC 633563
7, 8-Dihydroxycoumarin
Daphnetin
7,8-Dihydroxycoumarin
Chemical Name: 7,8-dihydroxy-2H-1-benzopyran-2-one
Smiles: OC1=CC=C2C=CC(=O)OC2=C1O
InChiKey: ATEFPOUAMCWAQS-UHFFFAOYSA-N
InChi: InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Yang, E.B., Zhao, Y.N., Zhang, K., et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem. Biophys. Res. Commun. 260(3), 682-685 (1999).
- Jiménez-Orozco, F.A., Rosales, A.A., Vega-López, A., et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur. J. Pharmacol. 668(1-2), 35-41 (2011).
- Lv, H., Liu, Q., Zhou, J., et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic. Biol. Med. 106, 38-52 (2017).
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