Description
MDK-8650, also known as PKC-theta inhibitor, is a selective PKC-θinhibitor, with an IC50 of 12 nM.
Product information
CAS Number: 736048-65-0
Molecular Weight: 454.45
Formula: C20H25F3N6O3
Synonym:
MDK8650
PKC-theta inhibito
Chemical Name: N4-((4-(aminomethyl)cyclohexyl)methyl)-5-nitro-N2-(2-(trifluoromethoxy)benzyl)pyrimidine-2,4-diamine
Smiles: NCC1CCC(CNC2=NC(NCC3=CC=CC=C3OC(F)(F)F)=NC=C2[N+]([O-])=O)CC1
InChiKey: HKOWATVSFKRXRW-UHFFFAOYSA-N
InChi: InChI=1S/C20H25F3N6O3/c21-20(22,23)32-17-4-2-1-3-15(17)11-26-19-27-12-16(29(30)31)18(28-19)25-10-14-7-5-13(9-24)6-8-14/h1-4,12-14H,5-11,24H2,(H2,25,26,27,28)
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambien...
Storage Condition: Dry, dark and -20 oC...
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
References:
- Cywin CL, Dahmann G, Prokopowicz AS 3rd, Young ER, Magolda RL, Cardozo MG, Cogan DA, Disalvo D, Ginn JD, Kashem MA, Wolak JP, Homon CA, Farrell TM, Grbic H, Hu H, Kaplita PV, Liu LH, Spero DM, Jeanfavre DD, O'Shea KM, White DM, Woska JR Jr, Brown ML. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med hem Lett. 2007 Jan 1;17(1):225-30. Epub 2006 Oct 19. PubMed PMID: 17055721.
Products are for research use only. Not for human use.
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