Description
Active-mono-sulfone-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 2055048-45-6
Molecular Weight: 767.88
Formula: C37H53NO14S
Chemical Name: 1-[(4-{2-[(4-methylbenzenesulfonyl)methyl]prop-2-enoyl}phenyl)formamido]-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid
Smiles: CC1C=CC(=CC=1)S(=O)(=O)CC(=C)C(=O)C1C=CC(=CC=1)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
InChiKey: YYYREZMWSVJNLW-UHFFFAOYSA-N
InChi: InChI=1S/C37H53NO14S/c1-30-3-9-34(10-4-30)53(43,44)29-31(2)36(41)32-5-7-33(8-6-32)37(42)38-12-14-46-16-18-48-20-22-50-24-26-52-28-27-51-25-23-49-21-19-47-17-15-45-13-11-35(39)40/h3-10H,2,11-29H2,1H3,(H,38,42)(H,39,40)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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