Description
NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell.
Product information
CAS Number: 2367641-24-3
Molecular Weight: 327.80
Formula: C19H18ClNO2
Chemical Name: 4,10-dimethoxy-7,8-dihydro-6λ⁵-azatetraphen-6-ylium chloride
Smiles: [Cl-].COC1C=CC=C2C=C3C4C=CC(=CC=4CC[N+]3=CC2=1)OC
InChiKey: OZPDXBXSBWNOGC-UHFFFAOYSA-M
InChi: InChI=1S/C19H18NO2.ClH/c1-21-15-6-7-16-14(10-15)8-9-20-12-17-13(11-18(16)20)4-3-5-19(17)22-2;/h3-7,10-12H,8-9H2,1-2H3;1H/q+1;/p-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells.
Products are for research use only. Not for human use.
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