NBD-125 - CAS# 2367641-24-3


Catalog No. Size PriceQuantity
M16459-C Contact sales@xcessbio.com for quotation $100

Description

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell.

Product information

CAS Number: 2367641-24-3

Molecular Weight: 327.80

Formula: C19H18ClNO2

Chemical Name: 4,10-dimethoxy-7,8-dihydro-6λ⁵-azatetraphen-6-ylium chloride

Smiles: [Cl-].COC1C=CC=C2C=C3C4C=CC(=CC=4CC[N+]3=CC2=1)OC

InChiKey: OZPDXBXSBWNOGC-UHFFFAOYSA-M

InChi: InChI=1S/C19H18NO2.ClH/c1-21-15-6-7-16-14(10-15)8-9-20-12-17-13(11-18(16)20)4-3-5-19(17)22-2;/h3-7,10-12H,8-9H2,1-2H3;1H/q+1;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells.

Products are for research use only. Not for human use.

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