Description
H-1152 is a selective inhibitor of ROCK. H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes. H-1152 is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
Product information
CAS Number: 451462-58-1
Molecular Weight: 319.42
Formula: C16H21N3O2S
Synonym:
H 1152
H1152
Chemical Name: 4-methyl-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline
Smiles: CC1=CN=CC2=CC=CC(=C12)S(=O)(=O)N1CCCNC[C@@H]1C
InChiKey: AWDORCFLUJZUQS-ZDUSSCGKSA-N
InChi: InChI=1S/C16H21N3O2S/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3/t13-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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