KW-8232 - CAS# 217813-15-5


Catalog No. Size PriceQuantity
M15963-C Contact sales@xcessbio.com for quotation $100

Description

KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

Product information

CAS Number: 217813-15-5

Molecular Weight: 687.25

Formula: C37H39ClN4O5S

Chemical Name: 4-({2-[4-(2-chlorophenyl)piperazine-1-carbonyl]-1-[2-(dimethylamino)ethyl]-1H-indol-3-yl}(4-hydroxyphenyl)methyl)phenyl methanesulfonate

Smiles: CN(C)CCN1C(=C(C(C2C=CC(O)=CC=2)C2C=CC(=CC=2)OS(C)(=O)=O)C2=CC=CC=C12)C(=O)N1CCN(CC1)C1=CC=CC=C1Cl

InChiKey: SUJJACDTWCALRH-UHFFFAOYSA-N

InChi: InChI=1S/C37H39ClN4O5S/c1-39(2)20-25-42-32-10-6-4-8-30(32)35(36(42)37(44)41-23-21-40(22-24-41)33-11-7-5-9-31(33)38)34(26-12-16-28(43)17-13-26)27-14-18-29(19-15-27)47-48(3,45)46/h4-19,34,43H,20-25H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (177.24 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells. KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM ).

In Vivo:

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.

Products are for research use only. Not for human use.

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