Description
PROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.
Product information
CAS Number: 1225383-38-9
Molecular Weight: 809.00
Formula: C44H64N4O10
Chemical Name: (2E, 4E, 6E)-9-[(3E)-3-{[({2-[2-(2-{[(2S)-2-[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoyl]oxy}ethoxy)ethoxy]ethyl}carbamoyl)methoxy]imino}-2, 6, 6-trimethylcyclohex-1-en-1-yl]-3, 7-dimethylnona-2, 4, 6, 8-tetraenoic acid
Smiles: CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)OCCOCCOCCNC(=O)CO/N=C1\CCC(C)(C)C(C=C/C(/C)=C/C=C/C(/C)=C/C(O)=O)=C\1C |t:44|
InChiKey: LJDTZKKSXVIAPQ-FATAJGLMSA-N
InChi: InChI=1S/C44H64N4O10/c1-30(2)26-38(47-42(53)41(52)36(45)28-34-14-9-8-10-15-34)43(54)57-25-24-56-23-22-55-21-20-46-39(49)29-58-48-37-18-19-44(6,7)35(33(37)5)17-16-31(3)12-11-13-32(4)27-40(50)51/h8-17,27,30,36,38,41,52H,18-26,28-29,45H2,1-7H3,(H,46,49)(H,47,53)(H,50,51)/b13-11+,17-16+,31-12+,32-27+,48-37+/t36-,38+,41+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
Products are for research use only. Not for human use.
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