Brevetoxin-3 - CAS# 85079-48-7

Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

Product information

CAS Number: 85079-48-7

Molecular Weight: 897.10

Formula: C50H72O14

Chemical Name: (1S, 3R, 4aR, 5aS, 6aR, 9aS, 10aR, 11aS, 12aR, 13R, 14aS, 15aR, 16aS, 20aR, 21aS, 22aR, 23aS, 25aR, 26aS, 27aR, 28aS, 29aR, 30aS, Z)-1-hydroxy-3-(2-(hydroxymethyl)allyl)-9a, 13, 20, 21a, 25a, 26a, 30a-heptamethyl-1, 2, 3, 4a, 5, 5a, 6a, 9, 9a, 10a, 11, 11a, 12a, 13, 14, 14a, 15a, 16, 16a, 20a, 21a, 22, 22a, 23a, 24, 25, 25a, 26a, 27, 27a, 28a, 29, 29a, 30a-tetratriacontahydro-18H-pyrano[2'''''', 3'''''':5''''', 6''''']pyrano[2''''', 3''''':5'''', 6'''']pyrano[2'''', 3'''':6''', 7''']oxepino[2''', 3''':6'', 7'']oxepino[2'', 3'':5', 6']pyrano[2', 3':5, 6]pyrano[3, 2-b]pyrano[2'', 3'':5', 6']pyrano[2', 3':5, 6]pyrano[2, 3-g]oxocin-18-one

Smiles: CC1=CC(=O)O[C@H]2C[C@H]3O[C@H]4C[C@@H](C)[C@H]5O[C@H]6C[C@H]7O[C@@]8(C)CC=C[C@H]9O[C@H]%10C[C@H]%11O[C@@H](C[C@H](O)[C@]%11(C)O[C@@H]%10C[C@@H]9O[C@@H]8C[C@]7(C)O[C@]6(C)CC[C@@H]5O[C@@H]4C[C@]3(C)O[C@H]12)CC(=C)CO |c:23|

InChiKey: BKMHDYJRAAJTAD-FGRVLNGBSA-N

InChi: InChI=1S/C50H72O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,26,28-42,44-45,51-52H,1,11-15,17-24H2,2-8H3/b10-9-/t26-,28-,29-,30+,31+,32+,33+,34-,35+,36-,37+,38-,39+,40-,41-,42-,44-,45-,46+,47-,48+,49+,50+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV).

In Vivo:

Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues. .

Products are for research use only. Not for human use.