QX-314 chloride - CAS# 5369-03-9


Catalog No. Size PriceQuantity
M17198-C Contact sales@xcessbio.com for quotation $100

Description

QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.

Product information

CAS Number: 5369-03-9

Molecular Weight: 298.85

Formula: C16H27ClN2O

Chemical Name: {[(2,6-dimethylphenyl)carbamoyl]methyl}triethylazanium chloride

Smiles: [Cl-].CC1C=CC=C(C)C=1NC(=O)C[N+](CC)(CC)CC

InChiKey: LLPPOMUAOGMYQI-UHFFFAOYSA-N

InChi: InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic). H2O : 50 mg/mL (167.31 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude.

Products are for research use only. Not for human use.

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