Description
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.
Product information
CAS Number: 5369-03-9
Molecular Weight: 298.85
Formula: C16H27ClN2O
Chemical Name: {[(2,6-dimethylphenyl)carbamoyl]methyl}triethylazanium chloride
Smiles: [Cl-].CC1C=CC=C(C)C=1NC(=O)C[N+](CC)(CC)CC
InChiKey: LLPPOMUAOGMYQI-UHFFFAOYSA-N
InChi: InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic). H2O : 50 mg/mL (167.31 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude.
Products are for research use only. Not for human use.
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