AMG8380 - CAS# 1642112-32-0


Catalog No. Size PriceQuantity
M17281-C Contact sales@xcessbio.com for quotation $100

Description

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.

Product information

CAS Number: 1642112-32-0

Molecular Weight: 543.93

Formula: C25H16ClF2N3O5S

Chemical Name: 1-{3'-chloro-2,5'-difluoro-5-methoxy-[1,1'-biphenyl]-4-yl}-N-(1,2-oxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide

Smiles: COC1=CC(=C(F)C=C1N1C(=O)C=CC2=CC(=CC=C12)S(=O)(=O)NC1C=CON=1)C1C=C(F)C=C(Cl)C=1

InChiKey: HXQNEKJQBGXFAG-UHFFFAOYSA-N

InChi: InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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