Description
Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.
Product information
CAS Number: 57530-40-2
Molecular Weight: 449.99
Formula: C22H28ClN3O3S
Chemical Name: ethyl N-{10-[3-(diethylamino)propanoyl]-10H-phenothiazin-2-yl}carbamate hydrochloride
Smiles: Cl.CCOC(=O)NC1=CC2=C(C=C1)SC1C=CC=CC=1N2C(=O)CCN(CC)CC
InChiKey: VHNXQKLWIQHSOY-UHFFFAOYSA-N
InChi: InChI=1S/C22H27N3O3S.ClH/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3;/h7-12,15H,4-6,13-14H2,1-3H3,(H,23,27);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator.
Products are for research use only. Not for human use.
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