Description
ETH 2120, also known as Sodium ionophore III, is a ionophore. Ionophore is suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode.
Product information
CAS Number: 81686-22-8
Molecular Weight: 552.79
Formula: C34H52N2O4
Synonym:
ETH-2120
Sodium ionophore III
ETH 2120
ETH2120
Chemical Name: N,N,N′,N′-Tetracyclohexyl-1,2-phenylenedioxydiacetamide
Smiles: O=C(COC1=CC=CC=C1OCC(=O)N(C1CCCCC1)C1CCCCC1)N(C1CCCCC1)C1CCCCC1
InChiKey: GKRBLFCTFPAHMH-UHFFFAOYSA-N
InChi: InChI=1S/C34H52N2O4/c37-33(35(27-15-5-1-6-16-27)28-17-7-2-8-18-28)25-39-31-23-13-14-24-32(31)40-26-34(38)36(29-19-9-3-10-20-29)30-21-11-4-12-22-30/h13-14,23-24,27-30H,1-12,15-22,25-26H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
Preincubation of the cells with the Na+ ionophore ETH 2120 not only stimulated caffeate reduction, but completely abolished ATP synthesis. Addition of ETH 2120 to cells in the steady state of caffeate reduction immediately dissipated the intracellular ATP level. Lactate-sulfate grown cells are insensitive to the Na+ ionophore, ETH 2120. ETH 2120 ligand is a very effective receptor for the Eu3+ and Am3+ cations and can be considered as a potential extraction agent for nuclear iste treatment.
References:
- Imkamp F, et al. Chemiosmotic energy conservation with Na(+) as the coupling ion during hydrogen-dependent caffeate reduction by Acetobacterium woodii. J Bacteriol. 2002 Apr;184(7):1947-51.
- Wang L, et al. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis. PeerJ. 2016 Apr 14;4:e1919.
- Makrlík, E, et al. Sodium Ionophore III as Very Effective Receptor for Trivalent Europium and Americium.J Solution Chem (2016) 45: 463.
Products are for research use only. Not for human use.
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