Description
E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities.
Product information
CAS Number: 2242635-03-4
Molecular Weight: 763.63
Formula: C24H29F2N11O8P2S2
Chemical Name: (14Z, 22S, 23S, 23aR, 25R, 27aR, 29R, 210R, 210aR, 212S)-23, 210-difluoro-25, 212-dimercapto-16, 19, 23, 23a, 27a, 29, 210, 210a, 214, 214a-decahydro-13H, 22H, 27H, 39H-4, 9-diaza-1, 3(9, 6)-dipurina-2(2, 9)-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecinacyclononaphan-6-ene 25, 212-dioxide, ammonia salt
Smiles: N.O=[P@]1(S)O[C@@H]2[C@H]3CO[P@](=O)(S)O[C@@H]4[C@@H](CO1)O[C@H]([C@@H]4F)N1C=NC4C(NCC=CCN=C5N=CNC6=C5N=CN6[C@@H](O3)[C@H]2F)=NC=NC1=4 |c:29|
InChiKey: JVSUYRKSTBVELL-NSCWAIDHSA-N
InChi: InChI=1S/C24H26F2N10O8P2S2.H3N/c25-13-17-11-5-39-46(38,48)44-18-12(6-40-45(37,47)43-17)42-24(14(18)26)36-10-34-16-20(30-8-32-22(16)36)28-4-2-1-3-27-19-15-21(31-7-29-19)35(9-33-15)23(13)41-11;/h1-2,7-14,17-18,23-24H,3-6H2,(H,37,47)(H,38,48)(H,27,29,31)(H,28,30,32);1H3/b2-1-;/t11-,12-,13-,14+,17-,18-,23-,24+,45+,46-;/m1./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively.
In Vivo:
In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model.
Products are for research use only. Not for human use.
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