Description
C-176 is a strong and covalent mouse STING inhibitor.
Product information
CAS Number: 314054-00-7
Molecular Weight: 358.09
Formula: C11H7IN2O4
Chemical Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Smiles: [O-][N+](=O)C1=CC=C(O1)C(=O)NC1C=CC(I)=CC=1
InChiKey: JBIKQXOZLBLMKI-UHFFFAOYSA-N
InChi: InChI=1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 62.5 mg/mL (174.54 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
In Vivo:
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice. C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1−/− mice.
Products are for research use only. Not for human use.
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