Description
Histone Acetyltransferase Inhibitor II (HAT Inhibitor II, compound 2c) is a potent, selective and cell-permeable p300 histone acetyltransferase (HAT) inhibitor with IC50 of 5 μM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.
Product information
CAS Number: 932749-62-7
Molecular Weight: 464.15
Formula: C20H16Br2O3
Synonym:
HAT Inhibitor II
Chemical Name: (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one
Smiles: OC1C=CC(/C=C2\CCC/C(=C\C3C=C(Br)C(O)=CC=3)/C\2=O)=CC=1Br
InChiKey: YOLKEKNTCBWPSD-VOMDNODZSA-N
InChi: InChI=1S/C20H16Br2O3/c21-16-10-12(4-6-18(16)23)8-14-2-1-3-15(20(14)25)9-13-5-7-19(24)17(22)11-13/h4-11,23-24H,1-3H2/b14-8+,15-9+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 93 mg/mL (200.37 mM) Ethanol 20 mg/mL (43.09 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Roberta Costi, et al. J Med Chem. 2007 Apr 19;50(8):1973-7.
Products are for research use only. Not for human use.
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