Description
CL264 is a TLR7-specific agonist for innate immune signals research.
Product information
CAS Number: 1510712-69-2
Molecular Weight: 413.43
Formula: C19H23N7O4
Chemical Name: 2-[(4-{[6-amino-2-(butylamino)-8-oxo-8,9-dihydro-7H-purin-9-yl]methyl}phenyl)formamido]acetic acid
Smiles: CCCCNC1=NC(N)=C2NC(=O)N(CC3C=CC(=CC=3)C(=O)NCC(O)=O)C2=N1
InChiKey: BXJWQQWEBUICHY-UHFFFAOYSA-N
InChi: InChI=1S/C19H23N7O4/c1-2-3-8-21-18-24-15(20)14-16(25-18)26(19(30)23-14)10-11-4-6-12(7-5-11)17(29)22-9-13(27)28/h4-7H,2-3,8-10H2,1H3,(H,22,29)(H,23,30)(H,27,28)(H3,20,21,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (60.47 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Toll like receptors (TLRs) are the best-studied class of receptors that are essential players in the detection of a range of lipid-, protein-, nucleic acid-based PAMPs. TLR7 is expressed predominantly in plasmacytoid dendritic cells (pDCs), macrophages and B cells. Many TLR7 modulators are interferon inducers, anti-cancer agents, anti-infectious agents, therapeutic agents for immunological diseases and vaccine adjuvants.
Products are for research use only. Not for human use.
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