Description
TAK438, also known as Vonoprazan Fumarate, is a new medicine for treating acid-related diseases with a novel mechanism of action called potassium-competitive acid blockers (P-CABs) which competitively inhibits the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. TAKECAB provides a strong and sustained acid secretion inhibitory effect.
Product information
CAS Number: 881681-01-2
Molecular Weight: 461.46
Formula: C21H20FN3O6S
Synonym:
Vonoprazan Fumarate
TAK 438
TAK438
Chemical Name: (2E)-but-2-enedioic acid; {[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrol-3-yl]methyl}(methyl)amine
Smiles: CNCC1C=C(C2=CC=CC=C2F)N(C=1)S(=O)(=O)C1=CN=CC=C1.OC(=O)/C=C/C(O)=O
InChiKey: ROGSHYHKHPCCJW-WLHGVMLRSA-N
InChi: InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (108.35 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
TAK-438 (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H+ , K+-ATPase activity in a concentration-dependent manner. Vonoprazan does not inhibit Na+, K+-ATPase activity, even at concentrations 500 times higher than their IC50 values against gastric H+, K+-ATPase activity.
In Vivo:
TAK-438 (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (2DG, 200 mg/kg s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.